General information
Organisation
The French Alternative Energies and Atomic Energy Commission (CEA) is a key player in research, development and innovation in four main areas :
• defence and security,
• nuclear energy (fission and fusion),
• technological research for industry,
• fundamental research in the physical sciences and life sciences.
Drawing on its widely acknowledged expertise, and thanks to its 16000 technicians, engineers, researchers and staff, the CEA actively participates in collaborative projects with a large number of academic and industrial partners.
The CEA is established in ten centers spread throughout France
Reference
SL-DRF-25-0123
Direction
DRF
Thesis topic details
Category
Corpuscular physics and outer space
Thesis topics
Development of a dosimetry system to track alpha particles in in vitro assays for Targeted Alpha Therapy
Contract
Thèse
Job description
Targeted Alpha Therapy (TAT) is a promising new method of treating cancer. It uses radioactive substances called alpha-emitting radioisotopes that are injected into the patient's body. These substances specifically target cancer cells, allowing the radiation to be concentrated where it is needed most, close to the tumors. Alpha particles are particularly effective because of their short range and ability to target and destroy cancer cells.
As with any new treatment, TAT must undergo preclinical studies to test its effectiveness and compare it to other existing treatments. Much of this research is done in laboratory, where cancer cells are exposed to these radioactive substances to observe their effects, such as cell survival. However, assessing the effects of alpha particles requires special methods because they behave differently than other types of radiation.
Recently, a method for measuring the radiation dose received by cells in laboratory experiments has been successfully tested. This method uses detecto
University / doctoral school
Physique, Sciences de l’Ingénieur, Matériaux, Énergie (PSIME)
Caen
Thesis topic location
Site
Saclay
Requester
Position start date
01/10/2025
Person to be contacted by the applicant
FRELIN-LABALME Anne-Marie
anne-marie.frelin@ganil.fr
CEA
DRF/IRFU//GANIL
GANIL
Boulevard Henri Becquerel
14076 Caen cedex
02 31 45 45 30
Tutor / Responsible thesis director
FRELIN-LABALME Anne-Marie
anne-marie.frelin@ganil.fr
CEA
DRF/IRFU//GANIL
GANIL
Boulevard Henri Becquerel
14076 Caen cedex
02 31 45 45 30
En savoir plus
https://www.ganil-spiral2.eu/wp-content/uploads/2024/10/DESYDOAL-thesis2025.pdf