Fully Homomorphic Encryption (FHE) is a technology that allows computations to be performed directly on encrypted data, meaning that we can process information without ever knowing its actual content. For example, it could enable online searches where the server never sees what you are looking for, or AI inference tasks on private data that remain fully confidential. Despite its potential, current FHE implementations remain computationally intensive and require substantial processing power, typically relying on high-end CPUs or GPUs with significant energy consumption. In particular, the bootstrapping operation represents a major performance bottleneck that prevents large-scale adoption. Existing CPU-based FHE implementations can take over 20 seconds on standard x86 architectures, while custom ASIC solutions, although faster, are prohibitively expensive, often exceeding 150 mm² in silicon area. This PhD project aims to accelerate the TFHE scheme, a more lightweight and efficient variant of FHE. The objective is to design and prototype innovative implementations of TFHE on RISC-V–based systems, targeting a significant reduction in bootstrapping latency. The research will explore synergies between hardware acceleration techniques developed for post-quantum cryptography and those applicable to TFHE, as well as tightly coupled acceleration approaches between RISC-V cores and dedicated accelerators. Finally, the project will investigate the potential for integrating a fully homomorphic computation domain directly within the processor’s instruction set architecture (ISA).