General information
Organisation
The French Alternative Energies and Atomic Energy Commission (CEA) is a key player in research, development and innovation in four main areas :
• defence and security,
• nuclear energy (fission and fusion),
• technological research for industry,
• fundamental research in the physical sciences and life sciences.
Drawing on its widely acknowledged expertise, and thanks to its 16000 technicians, engineers, researchers and staff, the CEA actively participates in collaborative projects with a large number of academic and industrial partners.
The CEA is established in ten centers spread throughout France
Reference
SL-DRF-26-0405
Direction
DRF
Thesis topic details
Category
Life Sciences
Thesis topics
Development of monoclonal antibodies for the diagnostic and the treatement of hypervirulent-Klebsiella pneumoniae
Contract
Thèse
Job description
For several years, we have observed the emergence of hypervirulent (hvKp) strains of Klebsiella pneumoniae that have become highly resistant to antibiotics. In a context of dwindling antibiotic options, monoclonal antibodies (Abs) directed against well-conserved capsular antigens of these hvKp strains appear as a promising therapeutic alternative.
This PhD project is structured around three complementary objectives:
1. To describe the circulation of hvKp clones through comparative genomic analysis of strains collected via the French National Reference Center for Antibiotic Resistance and through an international collaboration.
2. To produce and characterize monoclonal Abs directed against the HvKp capsule.
3. To develop a rapid detection tool based on MALDI-TOF profile analysis coupled with machine learning algorithms.
University / doctoral school
Innovation Thérapeutique: du Fondamental à l’Appliqué (ITFA)
Paris-Saclay
Thesis topic location
Site
Fontenay-aux-Roses
Requester
Position start date
01/10/2026
Person to be contacted by the applicant
DORTET Laurent 
laurent.dortet@aphp.fr
AP-HP
63 rue Gabiel Péri, 94270, Le Kremlin-Bicêtre
01 45 21 63 32
Tutor / Responsible thesis director
DORTET Laurent laurent.dortet@aphp.fr
AP-HP
63 rue Gabiel Péri, 94270, Le Kremlin-Bicêtre
01 45 21 63 32
En savoir plus
https://jacob.cea.fr/drf/ifrancoisjacob/Pages/Departements/IDMIT.aspx
