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Development of a dosimetry system to track alpha particles in in vitro assays for Targeted Alpha Therapy


Thesis topic details

General information

Organisation

The French Alternative Energies and Atomic Energy Commission (CEA) is a key player in research, development and innovation in four main areas :
• defence and security,
• nuclear energy (fission and fusion),
• technological research for industry,
• fundamental research in the physical sciences and life sciences.

Drawing on its widely acknowledged expertise, and thanks to its 16000 technicians, engineers, researchers and staff, the CEA actively participates in collaborative projects with a large number of academic and industrial partners.

The CEA is established in ten centers spread throughout France
  

Reference

SL-DRF-25-0123  

Direction

DRF

Thesis topic details

Category

Corpuscular physics and outer space

Thesis topics

Development of a dosimetry system to track alpha particles in in vitro assays for Targeted Alpha Therapy

Contract

Thèse

Job description

Targeted Alpha Therapy (TAT) is a promising new method of treating cancer. It uses radioactive substances called alpha-emitting radioisotopes that are injected into the patient's body. These substances specifically target cancer cells, allowing the radiation to be concentrated where it is needed most, close to the tumors. Alpha particles are particularly effective because of their short range and ability to target and destroy cancer cells.
As with any new treatment, TAT must undergo preclinical studies to test its effectiveness and compare it to other existing treatments. Much of this research is done in laboratory, where cancer cells are exposed to these radioactive substances to observe their effects, such as cell survival. However, assessing the effects of alpha particles requires special methods because they behave differently than other types of radiation.
Recently, a method for measuring the radiation dose received by cells in laboratory experiments has been successfully tested. This method uses detecto

University / doctoral school

Physique, Sciences de l’Ingénieur, Matériaux, Énergie (PSIME)
Caen

Thesis topic location

Site

Saclay

Requester

Position start date

01/10/2025

Person to be contacted by the applicant

FRELIN-LABALME Anne-Marie anne-marie.frelin@ganil.fr
CEA
DRF/IRFU//GANIL
GANIL
Boulevard Henri Becquerel
14076 Caen cedex
02 31 45 45 30

Tutor / Responsible thesis director

FRELIN-LABALME Anne-Marie anne-marie.frelin@ganil.fr
CEA
DRF/IRFU//GANIL
GANIL
Boulevard Henri Becquerel
14076 Caen cedex
02 31 45 45 30

En savoir plus


https://www.ganil-spiral2.eu/wp-content/uploads/2024/10/DESYDOAL-thesis2025.pdf