General information
Organisation
The French Alternative Energies and Atomic Energy Commission (CEA) is a key player in research, development and innovation in four main areas :
• defence and security,
• nuclear energy (fission and fusion),
• technological research for industry,
• fundamental research in the physical sciences and life sciences.
Drawing on its widely acknowledged expertise, and thanks to its 16000 technicians, engineers, researchers and staff, the CEA actively participates in collaborative projects with a large number of academic and industrial partners.
The CEA is established in ten centers spread throughout France
Reference
SL-DRT-24-0597
Direction
DRT
Thesis topic details
Category
Technological challenges
Thesis topics
Hollow microneedle and capillary microfluidic system for InterStitial Fluide (ISF) monitoring
Contract
Thèse
Job description
Interstitial fluid (ISF) is the fluid that occupies the space between blood capillaries and cells. ISF consists mainly of water, salts, sugars, hormones, neurotransmitters, CO2 and fatty acids. It is particularly interesting as it is described as a filtrate of plasma, but more accessible than blood for continuous monitoring. Continuous monitoring of ISF is targeted, for example, for cortisol (a marker of stress, whose circadian rhythm makes continuous monitoring very interesting), sex hormones (PMA) and other biomarkers for monitoring a patient's state of health. The aim of this thesis is to develop a wearable device for ISF sampling, which co-integrates biocompatible or even resorbable hollow microneedles and a capillary microfluidic part. Eventually, this type of system will be combinable with various types of sensors at the fluidic outlet for various applications such as circadian cortisol monitoring for stress and post-traumatic stress. Three main issues will need to be addressed in this thesis: (a) One is the management of very low flow rates in passive microfluidics (flow rates in the nL/min range). (b) Technologically, the manufacturing process for resorbable hollow microneedles with fine management of the surface finish of the channel interior (to promote capillarity) will also be an important focus of the study. (c) Finally, the process will be evaluated and improved in terms of eco-circularity.
University / doctoral school
Ecole Doctorale de Physique de Grenoble (EdPHYS)
Université Grenoble Alpes
Thesis topic location
Site
Grenoble
Requester
Position start date
01/10/2024
Person to be contacted by the applicant
BLAIRE Guillaume guillaume.blaire@cea.fr
CEA
DRT/DTIS/SEMIV/LSMB
17 avenue des martyrs, 38054 Grenoble Cedex 9
Tutor / Responsible thesis director
REVAUX Amélie amelie.revaux@cea.fr
CEA
DRT/DTBS//LMCD
CEA Grenoble
17 rue des martyrs, 38054 Grenoble cedex 09 – France
33 4 38 78 45 93
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