General information
Organisation
The French Alternative Energies and Atomic Energy Commission (CEA) is a key player in research, development and innovation in four main areas :
• defence and security,
• nuclear energy (fission and fusion),
• technological research for industry,
• fundamental research in the physical sciences and life sciences.
Drawing on its widely acknowledged expertise, and thanks to its 16000 technicians, engineers, researchers and staff, the CEA actively participates in collaborative projects with a large number of academic and industrial partners.
The CEA is established in ten centers spread throughout France
Reference
SL-DRF-26-0082
Direction
DRF
Thesis topic details
Category
Life Sciences
Thesis topics
Exploring mechanisms of action of vaccine induced protection against infectious diseases in humans
Contract
Thèse
Job description
The project aims at unravelling the molecular and cellular mechanisms that contribute to long-term protection induced by vaccines. Early changes (hours and days) occurring at site of injection and distant sites following vaccine injection will be correlated to long lasting (beyond 12 months) induction of neutralizing antibodies and specific T and B cell memory. A particular focus will be made to the relation of immune response with vaccine antigen persistence in the organisms. Multiple omics approaches will be applied to different tissue compartments of animals vaccinated with the yellow fever vaccine (Stamaril) known to induce a remarkable durable response, to then inform the design of new generation of anti-poxvirus vaccines.
University / doctoral school
Innovation Thérapeutique: du Fondamental à l’Appliqué (ITFA)
Paris-Saclay
Thesis topic location
Site
Fontenay-aux-Roses
Requester
Position start date
01/11/2025
Person to be contacted by the applicant
Le Grand Roger 
roger.le-grand@cea.fr
CEA
DRF
18 route du panorama, 92265 Fontenay-Aux-Roses, Cedex
0146548757
Tutor / Responsible thesis director
Le Grand Roger roger.le-grand@cea.fr
CEA
DRF
18 route du panorama, 92265 Fontenay-Aux-Roses, Cedex
0146548757
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