General information
Organisation
The French Alternative Energies and Atomic Energy Commission (CEA) is a key player in research, development and innovation in four main areas :
• defence and security,
• nuclear energy (fission and fusion),
• technological research for industry,
• fundamental research in the physical sciences and life sciences.
Drawing on its widely acknowledged expertise, and thanks to its 16000 technicians, engineers, researchers and staff, the CEA actively participates in collaborative projects with a large number of academic and industrial partners.
The CEA is established in ten centers spread throughout France
Reference
SL-DRF-24-0811
Direction
DRF
Thesis topic details
Category
Condensed Matter Physics, chemistry, nanosciences
Thesis topics
Exploring chemotaxis in magnetotactic bacteria
Contract
Thèse
Job description
Magnetotactic bacteria (MTB) are a diverse group of bacteria characterized by their capacity to biomineralize magnetite nanoparticles called magnetosomes. The latter allow MTB to passively align along magnetic field lines. This feature makes MTB of great interest to develop magnetic-guided microrobots used for medical applications such as targeted drug delivery. To make the latter efficient, it is not only essential to understand MTB magnetic behavior but also how MTB react to diverse chemical stimuli.
The aim of this internship is to broaden our understanding of chemotaxis in MTB. Several MTB species can be grown in the lab and will be investigated during the thesis. Typically, tethered cells and motility assays involving the use of microfluidics, microscopy and image analysis approaches will be developed to investigate, on a single-cell and population level, the chemotaxis responses of the strains to different chemical stimuli. These responses will be studied with bacteria grown in different growth conditions and in the absence or presence of a magnetic field using a custom-made magnetic microscope. Altogether, the data generated will give first insight into how MTB give an integrated response to chemical and magnetic stimuli and will therefore open new routes for the further development of targeted drug delivery.
University / doctoral school
Ecole Doctorale des Sciences Chimiques (SC)
Aix-Marseille Université
Thesis topic location
Site
Cadarache
Requester
Position start date
01/10/2024
Person to be contacted by the applicant
FAIVRE Damien damien.faivre@cea.fr
CEA
DRF/BIAM/SBVME/LBC
CEA Cadarache
Bat 1900
13108 Saint Paul Lez Durance Cedex
04 42 25 46 19
Tutor / Responsible thesis director
FAIVRE Damien damien.faivre@cea.fr
CEA
DRF/BIAM/SBVME/LBC
CEA Cadarache
Bat 1900
13108 Saint Paul Lez Durance Cedex
04 42 25 46 19
En savoir plus
https://www.cite-des-energies.fr/chercheur/damien-faivre/?lang=en
https://www.cite-des-energies.fr/en/home-biam/search/mem/