General information
Organisation
The French Alternative Energies and Atomic Energy Commission (CEA) is a key player in research, development and innovation in four main areas :
• defence and security,
• nuclear energy (fission and fusion),
• technological research for industry,
• fundamental research in the physical sciences and life sciences.
Drawing on its widely acknowledged expertise, and thanks to its 16000 technicians, engineers, researchers and staff, the CEA actively participates in collaborative projects with a large number of academic and industrial partners.
The CEA is established in ten centers spread throughout France
Reference
SL-DRF-24-0492
Direction
DRF
Thesis topic details
Category
Life Sciences
Thesis topics
Prion-like proteins in marine plankton: a quest towards new molecular factors of thermal adaptation
Contract
Thèse
Job description
Climate change is reshaping the distribution of species on the planet and mechanisms for adaptation to thermal stress are then called upon. Recently, in terrestrial plants the role of prion-like proteins has been highlighted in flowering and vernalization mechanisms. However, these atypical proteins have not been characterized in the marine world where plankton plays an essential role in the biological carbon pump and the marine food web. To explore the world of prion-like proteins and their role in thermal adaptation of marine plankton species, we propose a three years PhD program in the computational biology team of the CEA-SEPIA in the François Jacob Institute of Biology located in Fontenay-aux-Roses, France. The first objective of the thesis is to identify and characterize the function of marine prion-like proteins and their biogeography in the world oceans. The student will also reconstruct the molecular evolution of these proteins across a wide spectrum of marine plankton species through gain/loss and adaptation signal analyses. The research approach will be based on comparative genomics and phylogeny on Tara Oceans metagenomic and metatranscriptomic data. Additionally, the student will identify prion-like proteins involved in the adaptation to temperature by integrating spatial and environmental data collected by the Tara Oceans expeditions. In a context of climate change, this research fits into the understanding of the molecular evolution of prion-like proteins, shedding light on their role in the thermal adaptation of species playing a key role in the marine food chain and geochemical cycles.
University / doctoral school
Structure et Dynamique des Systèmes Vivants (SDSV)
Paris-Saclay
Thesis topic location
Site
Fontenay-aux-Roses
Requester
Position start date
01/09/2024
Person to be contacted by the applicant
MADOUI Amin mohammedamin.madoui@cea.fr
CEA
DRF/JACOB//LIDT
18 Route du Panorama
92265 Fontenay-aux-Roses
0146548105
Tutor / Responsible thesis director
MADOUI Amin mohammedamin.madoui@cea.fr
CEA
DRF/JACOB//LIDT
18 Route du Panorama
92265 Fontenay-aux-Roses
0146548105
En savoir plus
https://madoui.github.io/
https://jacob.cea.fr/drf/ifrancoisjacob/pages/departements/sepia.aspx