Lanthanide complexes with push-pull antennas for luminescence sensitisation have demonstrated their strong potential for cellular imaging, thanks in particular to their two-photon absorption properties, which enable excitation in the near infrared. As part of the MAGELLAN project, we are seeking to develop luminescent probes for multiplex biological imaging of cells, with two objectives: (1) to develop Yb3+-based probes for NIR-NIR imaging and (2) to develop probes capable of performing spatio-temporal imaging of O2 consumption and the production of reactive oxygen species (ROS = HOCl, H2O2) in macrophages, using Tb3+, Eu3+, Sm3+ and/or Yb3+ probes. To this end, we will design conjugates between lanthanide complexes and peptides or biological macromolecules (polysaccharides, polylysine, zymosan) in which the peptide or macromolecule will enable the lanthanide complex to be localised in the cytosol or phagosome of the macrophage or will constrain it in the extracellular environment. The PhD student recruited will have three objectives: (1) the synthesis and characterisation of lanthanide-based probes, (2) the evaluation in solution of their ability to detect ROS, and (2) their evaluation for two-photon microscopy and monitoring of ROS production or O2 consumption with macrophages.