General information
Organisation
The French Alternative Energies and Atomic Energy Commission (CEA) is a key player in research, development and innovation in four main areas :
• defence and security,
• nuclear energy (fission and fusion),
• technological research for industry,
• fundamental research in the physical sciences and life sciences.
Drawing on its widely acknowledged expertise, and thanks to its 16000 technicians, engineers, researchers and staff, the CEA actively participates in collaborative projects with a large number of academic and industrial partners.
The CEA is established in ten centers spread throughout France
Reference
SL-DRF-24-0590
Direction
DRF
Thesis topic details
Category
Condensed Matter Physics, chemistry, nanosciences
Thesis topics
Hyperpolarised, continuous-mode NMR based on parahydrogen and grafted catalysts
Contract
Thèse
Job description
Nuclear Nuclear magnetic resonance (NMR) is a robust, non-invasive technique of analysis. It provides valuable information about chemical reactions, which can then be better characterised and optimised. However, NMR is poorly sensitive, and low-concentrated solutes, such as intermediates of reaction, may be unobservable by conventional NMR. One method known to drastically but temporarily increase the sensitivity of NMR is to create a hyperpolarised state in the system of nuclear spins, i.e. a polarisation much greater than that accessible with available magnetic fields. One hyperpolarisation method uses the specific properties of parahydrogen. A catalyst is required to add parahydrogen to a multiple bond or a metal.
The present thesis will investigate the combined contribution of (i) parahydrogen-based hyperpolarisation [1], (ii) the grafting of the appropriate catalyst onto nanoparticles [2], and (iii) a continuous analysis method [3] to detect and identify chemical intermediates, areas in which the laboratory has acquired experience. This subject involves a major investment in instrumentation, as well as skills in synthetic chemistry and NMR.
The thesis will be carried out at NIMBE, a joint CEA/CNRS unit at CEA Saclay. The hyperpolarised NMR and the synthesis will take place under the respective responsibility of Gaspard HUBER, from LSDRM, and Stéphane CAMPIDELLI, from LICSEN. These two NIMBE laboratories are located in nearby buildings.
References:
[1] Barskiy et al, Prog. Nucl. Magn. Reson. Spectrosc. 2019, 33, 114-115,.
[2] Hijazi et al., Org. Biomol. Chem., 2018, 16, 6767-6772.
[3] Carret et al., Anal. Chem. 2018, 90, 11169-11173.
University / doctoral school
Sciences Chimiques: Molécules, Matériaux, Instrumentation et Biosystèmes (2MIB)
Paris-Saclay
Thesis topic location
Site
Saclay
Requester
Position start date
01/10/2024
Person to be contacted by the applicant
HUBER Gaspard gaspard.huber@cea.fr
CEA
DRF/IRAMIS/NIMBE/LSDRM
Laboratoire de Structure et Dynamique par Résonance Magnétique
DRF / IRAMIS / NIMBE
Bâtiment 125 - PC n°9
CEA Saclay
91191 Gif-sur-Yvette Cedex
FRANCE
01 69 08 64 82
Tutor / Responsible thesis director
HUBER Gaspard gaspard.huber@cea.fr
CEA
DRF/IRAMIS/NIMBE/LSDRM
Laboratoire de Structure et Dynamique par Résonance Magnétique
DRF / IRAMIS / NIMBE
Bâtiment 125 - PC n°9
CEA Saclay
91191 Gif-sur-Yvette Cedex
FRANCE
01 69 08 64 82
En savoir plus
https://iramis.cea.fr/Pisp/gaspard.huber/
https://iramis.cea.fr/nimbe/
https://iramis.cea.fr/Pisp/104/stephane.campidelli.html