General information
Organisation
The French Alternative Energies and Atomic Energy Commission (CEA) is a key player in research, development and innovation in four main areas :
• defence and security,
• nuclear energy (fission and fusion),
• technological research for industry,
• fundamental research in the physical sciences and life sciences.
Drawing on its widely acknowledged expertise, and thanks to its 16000 technicians, engineers, researchers and staff, the CEA actively participates in collaborative projects with a large number of academic and industrial partners.
The CEA is established in ten centers spread throughout France
Reference
SL-DRT-24-0505
Direction
DRT
Thesis topic details
Category
Technological challenges
Thesis topics
Multi-target capture strategy for micro total analysis systems
Contract
Thèse
Job description
The concentration of biomarkers and pathogens in biological samples is generally limited by the preparation of these samples after their collection. In addition, their detection, when based on an antibody-antigen capture reaction, can be difficult to optimize within biosensors. If the approach which consists of functionalizing a wall to capture molecules or particles flowing in a micro channel seems simple at first glance, the results are often below expectations. On the one hand, the capture of molecules is a convection-diffusion problem; on the other hand, capturing particles must also take into account the pressure distributions on them. Thus the proposed thesis subject is part of a project to optimize the capture and concentration of all types of biological and biochemical targets within fluidic microsystems.
The thesis project will begin by the exploration of models dedicated to the capture of biochemical and biological targets within a microchannel. The objective of this task is to specify the optimal and common conditions for capturing all targets of interest. Among all possible configurations, maintaining functionalized beads dispersed in volume by an adequate field will be favored because it is expected to be optimal. This configuration will be a subject of particular attention, especially as it offers an original microfluidic implementation, particularly in the study of organoids on chips to capture, concentrate and monitor their secretions.
For this project, the laboratory is looking for a student motivated by experimental work in microfluidics with a detailed understanding of the involved physical phenomena. In addition, knowledge of classic molecular biology tests will be appreciated. Skills in numerical simulation are also an asset when applying for the proposed thesis.
University / doctoral school
Ingénierie - Matériaux - Environnement - Energétique - Procédés - Production (IMEP2)
Université Grenoble Alpes
Thesis topic location
Site
Grenoble
Requester
Position start date
01/10/2024
Person to be contacted by the applicant
ROUX Jean-Maxime jean-maxime.roux@cea.fr
CEA
DRT/DTIS//LMTS
CEA-Leti
DRT/DTIS/SYSM/LMTS
17, rue des Martyrs
38054 GRENOBLE Cedex 9
FRANCE
04 38 78 01 03
Tutor / Responsible thesis director
DAVOUST Laurent laurent.davoust@hmg.inpg.fr
UGA
Grenoble INP - UMR 5266 - Science et ingénierie des matériaux et des procédés (SIMAP)
SIMAP
Science et Ingénierie des MAtériaux et Procédés
1130 rue de la Piscine - BP 75 - F-38402 ST MARTIN D HERES CEDEX
0476825206
En savoir plus
https://www.researchgate.net/profile/Jean-Maxime-Roux