Pause
Read
CEA vacancy search engine

Super-resolution of brain MR images: from research to the clinic through machine learning approaches.


Thesis topic details

General information

Organisation

The French Alternative Energies and Atomic Energy Commission (CEA) is a key player in research, development and innovation in four main areas :
• defence and security,
• nuclear energy (fission and fusion),
• technological research for industry,
• fundamental research in the physical sciences and life sciences.

Drawing on its widely acknowledged expertise, and thanks to its 16000 technicians, engineers, researchers and staff, the CEA actively participates in collaborative projects with a large number of academic and industrial partners.

The CEA is established in ten centers spread throughout France
  

Reference

SL-DRF-26-0202  

Direction

DRF

Thesis topic details

Category

Life Sciences

Thesis topics

Super-resolution of brain MR images: from research to the clinic through machine learning approaches.

Contract

Thèse

Job description

Magnetic Resonance Imaging (MRI) has become a reference modality for diagnosing and monitoring neurological disorders. However, acquiring high-resolution (HR) brain images remains challenging in clinical practice due to limited scan time, patient comfort constraints, and image degradation caused by patient motion. The increased signal enabled by higher magnetic field strengths can be invested to achieve higher spatial resolution within the same acquisition time. This project aims at taking advantage of the unprecedented spatial resolution achievable with the 11.7T Iseult MRI scanner, currently the most powerful MR scanner in the world, to train a machine learning-based super-resolution (SR) model that enhances the spatial resolution of 3T MRI images acquired in clinical practice. Current SR approaches are typically trained on public datasets, using pairs of high- and low-resolution images, with the low-resolution data synthetically generated from the high-resolution images. In this project we will use a real dataset consisting of 3T and 11.7T images acquired from the same cohort, ensuring higher anatomical fidelity and enabling a rigorous assessment of hallucination risks, i.e. of generating anatomically incorrect details that could be misinterpreted by the radiologists. The project will involve the following steps: improving the quality of 11.7T images (through motion correction and artifact reduction), acquiring pairs of images at 3T and 11.7T, developing and validating SR models, and finally assessing their generalizability on public datasets. This work supports the integration of reliable SR methods into clinical practice, allowing conventional MRI scanners to benefit indirectly from Iseult's unique capabilities.

University / doctoral school

Physique et Ingénierie: électrons, photons et sciences du vivant (EOBE)
Paris-Saclay

Thesis topic location

Site

Saclay

Requester

Position start date

01/09/2026

Person to be contacted by the applicant

LE STER Caroline caroline.lester@cea.fr
CEA
DRF/JOLIOT/NEUROSPIN/BAOBAB/METRIC
Neurospin, Bâtiment 145
CEA/Saclay
91191 Gif-sur-Yvette
0169085591

Tutor / Responsible thesis director

Boulant Nicolas nicolas.boulant@cea.fr
CEA
DRF/JOLIOT/NEUROSPIN/BAOBAB/METRIC
CEA-Saclay
Neurospin, Bat. 145
91191 Gif-sur-Yvette Cedex
+33 1 69 08 76 82

En savoir plus


https://metric.neurospin.fr/