General information
Organisation
The French Alternative Energies and Atomic Energy Commission (CEA) is a key player in research, development and innovation in four main areas :
• defence and security,
• nuclear energy (fission and fusion),
• technological research for industry,
• fundamental research in the physical sciences and life sciences.
Drawing on its widely acknowledged expertise, and thanks to its 16000 technicians, engineers, researchers and staff, the CEA actively participates in collaborative projects with a large number of academic and industrial partners.
The CEA is established in ten centers spread throughout France
Reference
SL-DRF-24-0268
Direction
DRF
Thesis topic details
Category
Life Sciences
Thesis topics
Biosynthesis and functional evaluation of novel antimicrobial peptides from mammalian gut microbiomes
Contract
Thèse
Job description
The WHO has identified antibiotic resistance as one of the major threats to human health. According to predictions, the number of deaths related to antibiotic resistance is estimated at 10 million a year by 2050. This situation is prompting scientists to find new molecules, ideally natural ones, whose structures and mode of action differ from those of conventional antibiotics, to overcome the phenomena of resistance. One promising alternative concerns antimicrobial peptides of the RiPPs family (ribosomally synthesized and post-translationally modified peptides) produced by bacteria. Numerous studies show that the intestinal microbiome plays a very important role in the health of the host. Among the mechanisms involved, the production of antimicrobial peptides appears to be of particular importance. Part of our collaborative work aims to identify new antimicrobial peptides from complex biological ecosystems using metagenomic methods. To date, we have identified ten potentially interesting sequences. In this project, we will focus on the biosynthesis as well as the biochemical and structural characterizations of the antimicrobial peptides. An important part of the project will be devoted to the biological activity of these compounds on resistant and multi-resistant pathogens to conventional antibiotics. Moreover, the mode of action and the toxicity of the most effective peptides will be addressed.
University / doctoral school
Chimie et Sciences du Vivant (EDCSV)
Université Grenoble Alpes
Thesis topic location
Site
Grenoble
Requester
Position start date
01/10/2024
Person to be contacted by the applicant
DUARTE Victor victor.duarte@cea.fr
CNRS
DRF/IRIG/DIESE/CBM/BIOCAT
CEA/Grenoble
17, Rue des Martyrs
38054 Grenoble cedex 09
0438789116
Tutor / Responsible thesis director
DUARTE Victor victor.duarte@cea.fr
CNRS
DRF/IRIG/DIESE/CBM/BIOCAT
CEA/Grenoble
17, Rue des Martyrs
38054 Grenoble cedex 09
0438789116
En savoir plus
https://www.cbm-lab.fr/BioCat
https://www.cbm-lab.fr/