General information
Organisation
The French Alternative Energies and Atomic Energy Commission (CEA) is a key player in research, development and innovation in four main areas :
• defence and security,
• nuclear energy (fission and fusion),
• technological research for industry,
• fundamental research in the physical sciences and life sciences.
Drawing on its widely acknowledged expertise, and thanks to its 16000 technicians, engineers, researchers and staff, the CEA actively participates in collaborative projects with a large number of academic and industrial partners.
The CEA is established in ten centers spread throughout France
Reference
SL-DRF-24-0287
Direction
DRF
Thesis topic details
Category
Life Sciences
Thesis topics
Development of therapeutic human monoclonal antibodies against virulence factors of Pseudomonas aeruginosa
Contract
Thèse
Job description
Monoclonal antibodies are increasingly used in clinical practice to treat cancers, inflammatory diseases and infectious diseases. They also represent a very promising alternative to antibiotics in the fight against multi-resistant bacteria. This project aims to isolate for therapeutic purposes human monoclonal antibodies targeting virulence factors of Pseudomonas aeruginosa. P. aeruginosa is becoming increasingly resistant to antibiotics and thus an important global public health threat. Furthermore, this bacterium is highly prevalent in cystic fibrosis patients and its acquisition is a major predictor of the severity of this disease. We have chosen to target two essential virulence factors of P. aeruginosa, the type III secretion system proteins PcrV, PscF,and PopB/PopD), and the type Vb secretion system protein Pdta protein. We propose to isolate and characterize human monoclonal antibodies against these factors in order to develop them as therapeutic molecules.
University / doctoral school
Chimie et Sciences du Vivant (EDCSV)
Université Grenoble Alpes
Thesis topic location
Site
Grenoble
Requester
Position start date
01/12/2023
Person to be contacted by the applicant
POIGNARD Pascal pascal.poignard@ibs.fr
UGA
IRIG/IBS
Institut de Biologie Structurale
Groupe CAID
Bâtiment CIBB
CAMPUS EPN
71, avenue des Martyrs
CS 20192
38042 Grenoble CEDEX 9
0457428667
Tutor / Responsible thesis director
POIGNARD Pascal pascal.poignard@ibs.fr
UGA
IRIG/IBS
Institut de Biologie Structurale
Groupe CAID
Bâtiment CIBB
CAMPUS EPN
71, avenue des Martyrs
CS 20192
38042 Grenoble CEDEX 9
0457428667
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