General information
Organisation
The French Alternative Energies and Atomic Energy Commission (CEA) is a key player in research, development and innovation in four main areas :
• defence and security,
• nuclear energy (fission and fusion),
• technological research for industry,
• fundamental research in the physical sciences and life sciences.
Drawing on its widely acknowledged expertise, and thanks to its 16000 technicians, engineers, researchers and staff, the CEA actively participates in collaborative projects with a large number of academic and industrial partners.
The CEA is established in ten centers spread throughout France
Reference
SL-DRF-24-0153
Direction
DRF
Thesis topic details
Category
Life Sciences
Thesis topics
Imagerie de la compartimentation et de la pharmacologie du lithium par IRM du Lithium-7 in vivo at très haut champ magnétique.
Contract
Thèse
Job description
At ultra-high magnetic field, increased polarization opens the way for the NMR imaging and spectroscopy of exotic nuclei such as Lithium-7 (7Li) and Sodium-23 (23Na) with unprecedented sensitivities.
During this PhD thesis, the goal will be to develop, validate and apply 23Na and 7Li preclinical imaging protocols in the context of the new 11.7T Iseult MRI scanner of NeuroSpin (CEA/DRF/JOLIOT) as well as on its 17.2 T preclinical scanner. The PhD student will continue the work realized these last years on 23Na and 7Li imaging and will push for better and more significant NRM data. Our focus will be to use these methods to study the pharmacology and biophysical properties of Lithium in the brain. In particular, we aim at investigating the transport kinetics of Li+ through the Blood-Brain-Barrier, its compartmentation and its competition with Na+ ions.
University / doctoral school
Physique et Ingénierie: électrons, photons et sciences du vivant (EOBE)
Thesis topic location
Site
Saclay
Requester
Position start date
01/10/2022
Person to be contacted by the applicant
BOUMEZBEUR FAWZI 
fawzi.boumezbeur@cea.fr
CEA
DRF/JOLIOT/NEUROSPIN/BAOBAB/CIEL
Centre de Saclay,
NeuroSpin
Batiment 145
91191 Gif-sur-Yvette Cedex
0169089435
Tutor / Responsible thesis director
BOUMEZBEUR FAWZI fawzi.boumezbeur@cea.fr
CEA
DRF/JOLIOT/NEUROSPIN/BAOBAB/CIEL
Centre de Saclay,
NeuroSpin
Batiment 145
91191 Gif-sur-Yvette Cedex
0169089435
En savoir plus
http://joliot.cea.fr/drf/joliot/Pages/Entites_de_recherche/neurospin/UNIRS/Equipe-Metabolisme-Imagerie.aspx
http://joliot.cea.fr/drf/joliot/Pages/Entites_de_recherche/neurospin/UNIRS.aspx
https://fr.wikipedia.org/wiki/NeuroSpin
